ABSTRACT
In recent years, graphene and its derivatives, owing to their phenomenal surface, and mechanical, electrical, and chemical properties, have emerged as advantageous materials, especially in terms of their potential for antimicrobial applications. Particularly important among graphene's derivatives is graphene oxide (GO) due to the ease with which its surface can be modified, as well as the oxidative and membrane stress that it exerts on microbes. This review encapsulates all aspects regarding the functionalization of graphene-based materials (GBMs) into composites that are highly potent against bacterial, viral, and fungal activities. Governing factors, such as lateral size (LS), number of graphene layers, solvent and GBMs' concentration, microbial shape and size, aggregation ability of GBMs, and especially the mechanisms of interaction between composites and microbes are discussed in detail. The current and potential applications of these antimicrobial materials, especially in dentistry, osseointegration, and food packaging, have been described. This knowledge can further drive research that aims to look for the most suitable components for antimicrobial composites. The need for antimicrobial materials has seldom been more felt than during the COVID-19 pandemic, which has also been highlighted here. Possible future research areas include the exploration of GBMs' ability against algae.